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Accidental pollution in the Danube River Basin can cause widespread damage to the environment, and endanger the health of local people and the state of local economies downstream. This was exemplified by the effects of the Baia Mare cyanide spill in Romania in 2000 or by the Hungarian redsludge accident at Ajka in 2010. The ICPDR is working to prevent accidental pollution and to improve response capability by compiling an inventory of all relevant "Accident Risk Spots".

The habitats created by the Danube and its tributaries host a unique mix of species. But many habitats are degraded by man-made changes to the river profile and width, water depth and flow velocity following the construction of dams, weirs and canals. Many migratory fish including sturgeon species and the Danube Salmon are endangered or close to extinction by being disconnected from their spawning grounds and habitats or by being over-exploited.

A river does not end at its bank. The Danube and its tributaries form many diverse riverine habitats, including intricate networks of water bodies, creeks and channels, floodplain forests, water meadows, lakes, gravel islands, sandy banks and the unique delta habitats by the shores of the Black Sea.

The Danube and its tributaries host a variety of fascinating and diverse ecological territories with many unique plants and animals. The rich and unique biodiversity and riverine habitats have been under severe pressure due to human activities for centuries. However, today the protection of environment and biodiversity is on the political agenda of the different Danubian States.