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North Macedonia, officially the Republic of North Macedonia, is a landlocked country in Southeast Europe. Its terrain is mostly rugged, located between the Šar Mountains and Osogovo, which frame the valley of the Vardar River. Three large lakes - Lake Ohrid, Lake Prespa, and Dojran Lake - lie on the southern borders, bisected by the frontiers with Albania and Greece. Ohrid is considered one of the world's oldest lakes and biotopes.

The Accident Prevention & Control Expert Group (APC EG) deals with ICPDR activities concerning the prevention and management of accidental pollution.

The Accident Emergency Warning System (AEWS) of the Danube River Basin is activated whenever there is a risk of transboundary water pollution, or threshold danger levels of certain hazardous substances are exceeded.