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Historically, the Danube and some of its tributaries have formed important trade routes across Europe. The harnessing of these rivers to facilitate navigation has radically changed their physical and ecological characteristics, while pollution from ships and boats is also a significant problem. In order to address this problem, the ICPDR is undertaking various activities.

The Danube River Basin is Europe's second largest river basin, with a total area of 801,463 km². It is the world's most international river basin, flowing through the territory of 19 countries. The ecosystems of the Danube River Basin are highly valuable in environmental, economic, historical and social terms, but they are subject to increasing pressure and serious threats of pollution from agriculture, industry and cities.

The Danube is a major economic, geographical and cultural force in Austria. Draining over 96% of the country’s territory, the basin is home to 7.7 million people. In a country dominated by the Alps, the flat lands provided by the rivers are vital for the agricultural sector, human settlements and infrastructure. The Austrian territory accounts for 10% of the total area of the Danube Basin.

Since the 16th century, people have been changing the natural course of the rivers in the Danube River Basin, mainly for flood defence, hydropower generation and navigation. All these changes affect the ecological quality of the rivers. Changes in the depth or width of a river typically reduce flow rates, interrupting natural sediment transportation as well as the migration routes of animals.

A river does not end at its bank. The Danube and its tributaries form many diverse riverine habitats, including intricate networks of water bodies, creeks and channels, floodplain forests, water meadows, lakes, gravel islands, sandy banks and the unique delta habitats by the shores of the Black Sea.

Agriculture has long been a major source of income for many people living in the Danube River Basin. Today however, it is also a major source of pollutants – including fertilizers and pesticides and facing emerging issues like water scarcity and droughts.