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North Macedonia, officially the Republic of North Macedonia, is a landlocked country in Southeast Europe. Its terrain is mostly rugged, located between the Šar Mountains and Osogovo, which frame the valley of the Vardar River. Three large lakes - Lake Ohrid, Lake Prespa, and Dojran Lake - lie on the southern borders, bisected by the frontiers with Albania and Greece. Ohrid is considered one of the world's oldest lakes and biotopes.

A recent large-scale modelling study has shown that restoring floodplains and reconnecting cut-off water bodies with the Danube River, and its tributaries could play a significant role in improving water quality and removing nitrate pollution in the Danube River Basin.

Kolotar, 4 October 2010. The acute toxic risk deriving from the heavy metals in the red sludge is rather low, as their concentrations are rather low. However, the chronic toxicity threat is high.