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The Joint Action Programme of the ICPDR outlined the specific steps that were agreed to be taken over the period 2001-2005 to achieve the environmental objectives outlined in the Danube River Protection Convention including many large-scale measures to reduce water pollution, to promote nature conservation, to restore ecosystems, and to safeguard the long-term sustainable management of the environment.

The Accident Emergency Warning System (AEWS) of the Danube River Basin is activated whenever there is a risk of transboundary water pollution, or threshold danger levels of certain hazardous substances are exceeded.

Accidental pollution in the Danube River Basin can cause widespread damage to the environment, and endanger the health of local people and the state of local economies downstream. This was exemplified by the effects of the Baia Mare cyanide spill in Romania in 2000 or by the Hungarian redsludge accident at Ajka in 2010. The ICPDR is working to prevent accidental pollution and to improve response capability by compiling an inventory of all relevant "Accident Risk Spots".

The best way to protect and manage water is by close international co-operation between all the countries within the river basin – bringing together all interests upstream and downstream. All countries of the European Union are using a river basin approach for water management since the adoption of the EU Water Framework Directive.

Floods are natural phenomena. They can, however, turn into disasters causing widespread damage, health problems and even deaths. This is especially the case where rivers have been cut off from their natural floodplains, are confined to man-made channels, and where houses and industrial sites have been constructed in areas that are naturally liable to flooding.