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The ICPDR serves as a conduit for collaboration between Danube countries and the Black Sea region in matters necessitating coordinated action. It also collaborates with other international organizations in other river basins to tackle emerging challenges linked to water management (e.g., climate change adaptation). Partnerships with relevant international organizations to effectively address emerging challenges associated with water management, such as climate change adaptation are also part of the ICPDR's coopertaion activities.

Accidental pollution events are dangerous form of water contamination by hazardous substances. Industrial facilities, mining areas and contaminated sites that store, process or produce such substances in substantial amounts pose hazard (potential risk) to water. To avoid pollution accidents appropriate prevention measures have to be in place.