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In the Danube River Basin, five main pressures that affect water status: organic substance pollution, nutrient pollution, hazardous substance pollution, hydromorphological alterations and effects of climate change (drought, water scarcity, extreme hydrological phenomena and other impacts), have been identified as Significant Water Management Issues (SWMIs). The groundwater quantity and quality are also under constant pressure.

The ICPDR serves as a conduit for collaboration between Danube countries and the Black Sea region in matters necessitating coordinated action. It also collaborates with other international organizations in other river basins to tackle emerging challenges linked to water management (e.g., climate change adaptation). Partnerships with relevant international organizations to effectively address emerging challenges associated with water management, such as climate change adaptation are also part of the ICPDR's coopertaion activities.