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The Secretariat of the ICPDR is located at the United Nations Office at Vienna (UNOV). A team of approximately 10 staff members support the work of the ICPDR and its expert & task groups, assist with project development and implementation, and maintains the ICPDR's 'DANUBIS' information system.

The ICPDR comprises 15 Contracting Parties who have committed themselves to implement the Danube River Protection Convention.

The final goals are to co-operate on fundamental water management issues and to take all appropriate legal, administrative and technical measures to maintain and improve the quality of the Danube River and its environment.

The Danube River is seeing an influx of new non-native species, stemming from the increasing interconnections with various European and global water bodies via canals and other waterways designed to facilitate navigation. It is currently believed that alien species are very likely to become even more significant in the future, as the importance of the Danube as an international waterway increases.