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Organic pollution has been on the rise in the Danube over the last century, as human activities have resulted in increasing loads of wastewater rich in organic matter. The most serious organic pollution problems occur in tributaries that regularly receive untreated or inadequately treated wastewater from industrial plants and municipalities. Thanks to the significant improvement of wastewater infrastructure and services in the Danube countries, the basin-wide organic emissions reduced by 60% since the mid 2000s.

Historically, the Danube and some of its tributaries have formed important trade routes across Europe. The harnessing of these rivers to facilitate navigation has radically changed their physical and ecological characteristics, while pollution from ships and boats is also a significant problem. In order to address this problem, the ICPDR is undertaking various activities.