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The floodplains and wetlands of the Danube basin are uniquely valuable ecosystems in global terms, although few areas are still in their natural or near-natural state.

Since the 16th century, people have been changing the natural course of the rivers in the Danube River Basin, mainly for flood defence, hydropower generation and navigation. All these changes affect the ecological quality of the rivers. Changes in the depth or width of a river typically reduce flow rates, interrupting natural sediment transportation as well as the migration routes of animals.

Historically, the Danube and some of its tributaries have formed important trade routes across Europe. The harnessing of these rivers to facilitate navigation has radically changed their physical and ecological characteristics, while pollution from ships and boats is also a significant problem. In order to address this problem, the ICPDR is undertaking various activities.