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Accidental pollution in the Danube River Basin can cause widespread damage to the environment, and endanger the health of local people and the state of local economies downstream. This was exemplified by the effects of the Baia Mare cyanide spill in Romania in 2000 or by the Hungarian redsludge accident at Ajka in 2010. The ICPDR is working to prevent accidental pollution and to improve response capability by compiling an inventory of all relevant "Accident Risk Spots".

The Danube is a major economic, geographical and cultural force in Austria. Draining over 96% of the country’s territory, the basin is home to 7.7 million people. In a country dominated by the Alps, the flat lands provided by the rivers are vital for the agricultural sector, human settlements and infrastructure. The Austrian territory accounts for 10% of the total area of the Danube Basin.