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The ICPDR serves as a conduit for collaboration between Danube countries and the Black Sea region in matters necessitating coordinated action. It also collaborates with other international organizations in other river basins to tackle emerging challenges linked to water management (e.g., climate change adaptation). Partnerships with relevant international organizations to effectively address emerging challenges associated with water management, such as climate change adaptation are also part of the ICPDR's coopertaion activities.

The Danube River Basin is Europe's second largest river basin, with a total area of 801,463 km². It is the world's most international river basin, flowing through the territory of 19 countries. The ecosystems of the Danube River Basin are highly valuable in environmental, economic, historical and social terms, but they are subject to increasing pressure and serious threats of pollution from agriculture, industry and cities.