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The ICPDR serves as a conduit for collaboration between Danube countries and the Black Sea region in matters necessitating coordinated action. It also collaborates with other international organizations in other river basins to tackle emerging challenges linked to water management (e.g., climate change adaptation). Partnerships with relevant international organizations to effectively address emerging challenges associated with water management, such as climate change adaptation are also part of the ICPDR's coopertaion activities.

Accidental pollution in the Danube River Basin can cause widespread damage to the environment, and endanger the health of local people and the state of local economies downstream. This was exemplified by the effects of the Baia Mare cyanide spill in Romania in 2000 or by the Hungarian redsludge accident at Ajka in 2010. The ICPDR is working to prevent accidental pollution and to improve response capability by compiling an inventory of all relevant "Accident Risk Spots".