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Accidental pollution in the Danube River Basin can cause widespread damage to the environment, and endanger the health of local people and the state of local economies downstream. This was exemplified by the effects of the Baia Mare cyanide spill in Romania in 2000 or by the Hungarian redsludge accident at Ajka in 2010. The ICPDR is working to prevent accidental pollution and to improve response capability by compiling an inventory of all relevant "Accident Risk Spots".

Many people consider droughts to be rare, but in fact they are a normal and recurrent feature of the climate. Drought events are regional phenomena, affecting transnational water management. Unfortunately, droughts have a high damage potential: economic losses, ecological damages, and implications on human health.