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The EU Water Framework Directive aims to make all waters cleaner and healthier. To meet these requirements, the ICPDR's Danube River Basin Management Plan closely examines the most important pressures affecting water status.
Significant water management issues, called SWMIs, are the central pressures of basin-wide importance affecting the ecological and chemical status of surface waters, including pollution by organic substances, nutrients, and hazardous substances, as well as hydromorphological alterations. The first interim overview on the Significant Water Management Issues was created in 2007 for the 1st DRBM. The SWMIs outlined in this report were derived based on the requirements of the WFD and mainly related to quality aspects. For transboundary groundwater bodies, both qualitative and quantitative issues are addressed.

On 26-28 Feb 2006 an international conference on the Conservation and Sustainable Development of the Danube Delta took place in Odessa, Ukraine, under the aegis of UNESCO and ICPDR. The aim of the conference was to generate a vision for the conservation and sustainable develoment of the Danube Delta.

As both the largest remaining natural wetland and second largest river delta in Europe, the Danube Delta is one of the continent's most valuable habitats for wetland wildlife. Pollution and discharge manipulation from upstream has a huge effect on this area of high biodiversity, plus the delta continues to change ecologically itself – the Danube Delta spreads seaward at a rate of 10 to 25 metres every year.