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Following a request by the Danube Ministerial Conference 2010, the ICPDR has become active in initiating a dialogue with representatives from the hydropower sector. As an essential step in this process, "Guiding Principles on Sustainable Hydropower Development in the Danube Basin" have been developed by an interdisciplinary team and were finalised and adopted in June 2013.

On 26-28 Feb 2006 an international conference on the Conservation and Sustainable Development of the Danube Delta took place in Odessa, Ukraine, under the aegis of UNESCO and ICPDR. The aim of the conference was to generate a vision for the conservation and sustainable develoment of the Danube Delta.

As both the largest remaining natural wetland and second largest river delta in Europe, the Danube Delta is one of the continent's most valuable habitats for wetland wildlife. Pollution and discharge manipulation from upstream has a huge effect on this area of high biodiversity, plus the delta continues to change ecologically itself – the Danube Delta spreads seaward at a rate of 10 to 25 metres every year.